Centre Wesley Fofana will earn his first cap for France when they take on Italy in their Six Nations opener.
The 24-year-old will line up alongside Clermont Auvergne team-mate Aurelien Rougerie in midfield for coach Philippe Saint-Andre's first game in charge on Saturday at the Stade de France.
Francois Trinh-Duc takes over at fly-half from Morgan Parra who, after starting the World Cup final against New Zealand, drops to the bench.
France team to face Italy in the RBS 6 Nations on Saturday, February 4 at Stade de France (kick-off 2.30pm GMT): M Medard (Toulouse); V Clerc (Toulouse), A Rougerie (Clermont Auvergne), W Fofana (Clermont Auvergne), J Malzieu (Clermont Auvergne); F Trinh-Duc (Montpellier), D Yachvili (Biarritz); V Debaty (Clermont Auvergne), W Servat (Toulouse), N Mas (Perpignan), P Pape (Stade Francais), L Nallet (Racing Metro), T Dusautoir (capt, Toulouse), J Bonnaire (Clermont Auvergne), L Picamole (Toulouse).
Replacements: D Szarzewski (Stade Francais), J-B Poux (Toulouse), Y Maestri (Toulouse), I Harinordoquy (Biarritz), M Parra (Clermont Auvergne), L Beauxis (Toulouse), M Mermoz (Perpignan).
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